2week Menicon PremiO

Menicon PremiO is an advanced silicone hydrogel contact lens from Menicon with MeniSilk & Nanogloss technology.
The lens features a balanced combination of oxygen permeability (Dk 129) and water content (40%).

2week Menicon PremiO | Package

Menicon PremiO MeniSilk & Nanogloss Technology

Menicon PremiO with MeniSilk & Nanogloss technologies

The Company's pursuit of perfection

Spanning more than 60 years of history, Menicon’s goal has been to develop safe and effective contact lenses. For this purpose, the company’s R&D departments have focused for decades on developing hyper-oxygen transmissible contact lens materials, as it is well known that this is one of the most important features for safe contact lens wear. In 1979, the founder of Menicon, Mr Kyoichi Tanaka, patented the first silicone hydrogel (SiH) material in the world for use in the manufacture of contact lenses.1 In 2001, Menicon successfully launched the Menicon Z lens with the highest oxygen permeability of all gas permeable lenses available worldwide and the only one approved by the FDA for up to 30 days of continuous wear.

Menicon PremiO with MeniSilk and Nanogloss technologies, Menicon joins the few manufacturers in the world which distributes contact lenses made of this innovative material. The purpose of this article is to explain the unique features of the unrivalled Menicon PremiO silicone hydrogel contact lens.

Premio Box

Figure 1. Menicon PremiO lenses

Development of silicone hydrogel contact lenses

Hydrogel soft contact lens wear has been associated with a number of changes to the ocular surface, many of which have been related to hypoxia. 2 The introduction of silicone hydrogel contact lenses has eliminated most hypoxia-related complications; 3-5 however, early generations of these lenses have not solved other complications.

Adverse events associated with mechanical trauma such as superior epithelial arcuate lesions, localized papillary conjunctivitis and conjunctival epithelial flaps occur at higher rates of incidence than those reported with hydrogel contact lenses and might be attributed to the lens’ modulus of rigidity and inadequate lens fitting characteristics. 6, 7

Early generations of these lenses were developed to meet the minimum levels of oxygen transmissibility proposed to avoid hypoxia during continuous wear of contact lenses. 8, 9 However, the latter has been at the expense of increased modulus of rigidity and reduced wettability, water content and lubricity. 10-12 Furthermore, 7 years after the launch of these lenses, it is well know that continuous wear of contact lenses has not been well accepted by practitioners. 13 Subsequent generations of SiH contact lenses, manufactured with lower modulus of rigidity and higher water contents, have shown better comfort rates, lower incidences of mechanically-related adverse events, decreased lens surface deposition and increased lens wettabilities compared to first generations of SiH contact lenses. 6, 7

Hypoxia being virtually eliminated with SiH contact lenses, the other issue of special relevance for contact lens users is comfort. Discontinuation of contact lens wear occurs as a result of poor comfort in 72% of cases, 14 with dryness being the most commonly reported symptom. 15-17 Symptoms of discomfort and dryness have been related to lens movement and edge profiles; 7,18 lens dehydration; 19 protein and lipid deposition; 20 high modulus of rigidity, poor wettability and lubricity; 21,22 and solution toxicity. 23,24 Furthermore, initial contact lens comfort during trial fitting has been shown to greatly influence patients’ perception of contact lenses, and this might have an effect on the ultimate success of contact lens wear. 25,26 The relatively stiff nature of SiH contact lenses to conventional hydrogel lenses suggests that the lens-to-cornea curvature relationship may be more critical to fitting in the former lens compared to the latter. 27

Menicon's requirements for the development of Menicon PremiO

The Menicon PremiO with MeniSilk and Nanogloss technologies was developed taking into account the problems found with early generations of SiH contact lenses. The properties of this advanced lens are possibly the most balanced of all SiH contact lenses currently available on the market (Table 1).


Material asmofilcon A
Center thickness 0.08mm (-3.00D)
Water content 40%
Oxygen permeability 129
Oxygen transmissibility 161
Diameter 14.0mm
Base curves 8.3mm / 8.6mm
Power range -6.50D to -13.00D (0.50D steps)
+6.00D to -6.50D (0.25D steps)
Wearing shedule Daily wear and up to 7 days extended
Replacement cycle Every two weeks


In material science, the gas permeability of a membrane is defined as the product of diffusivity of the material to the gas (D) and the solubility (S) of the gas within the membrane material. In the contact lens field, solubility is normally represented as “k”, so permeability is known as Dk. However, the amount of oxygen which reaches the cornea through a manufactured contact lens does not only depend on the material, but also on the lens thickness. For example, if two lenses are manufactured with the same material, but one is two times thicker than the other, the amount of oxygen which reaches the cornea through the thicker lens would be half of that through the thinner lens. This is known as oxygen transmissibility and is represented by the product of diffusivity of the material divided by the lens thickness (Dk/t). 12

Holden and Mertz, and Harvitt and Bonanno estimated that contact lenses need to be manufactured with oxygen transmissibility values of 87 and 125 units, 33,34 respectively to prevent hypoxia during closed eye conditions. Although extended wear of contact lens still represent a small amount of the contact lens wearing population, it is believed that a substantial number of wearers take naps with their lenses. 13 Furthermore, oxygen transmissibility of contact lenses is normally measured through the centre of a -3.00D lens. However, the thickness profile of a contact lens changes from the centre to the periphery of the lens. Negative-powered lenses are thinner in the centre than in the periphery, whereas the opposite occurs with positive-powered lenses.

Menicon PremiO, with an extraordinarily high oxygen transmissibility of 161 units, prevents hypoxia across all parts of the lens and for all lens powers regardless of whether lenses are worn under open or closed eye conditions (Figures 2 and 3).

Figure 2
Relationship between oxygen permeability and water content for different hydrogel and silicone hydrogel contact lenses.

Figure 3
Oxygen transmissibility (Dk/t) of different silicone hydrogel contact lenses for different lens powers.


The transport of fluid and ions through contact lenses is crucial for the provision of essential nutrients and removal of waste products and debris. The flow of water through the lens is also necessary for on-eye lens movement, comfort and wettability. With hydrogel lenses, as the oxygen permeability increases, water content also increases. However, the opposite occurs with SiH contact lenses. The Menicon PremiO lens has been developed with high water content, while maintaining a well balanced modulus of rigidity and oxygen permeability (Figure 2).


The surface characteristics of a contact lens govern the interaction of the lens with the tear film and ocular structures. Therefore, the nature of the material surface can have a vital effect on comfort, wearing time and clarity of vision. In order to achieve this, the Nanogloss technology of the Menicon PremiO lens provide a highly controlled smooth surface reproducibility which warrants unmatched levels of comfort throughout the whole day. 28,29 Atomic Force Microscopy images supports the production of a smooth surface in the Menicon PremiO lens compared to early generations of plasma treated or coated SiH lenses (Figure 4).

Figure 4. Atomic Force Microscopy images (20x20 μm) of different silicone hydrogel contact lenses showing the smoothness of the Menicon PremiO vs. other silicone hydrogel lenses.


The surface wettability of a contact lens is of key importance in maintaining stable vision, comfort and biocompatibility of the lens with the ocular structures.
Furthermore, contact lens surfaces with poor wettabilities also have a greater tendency to attract deposits. Traditional methods of measuring wettability in vitro involve the measurement of contact angles. 30 Recently, advanced interference-based techniques of measuring wettability have been proposed. 31 During the polymerisation process, the MeniSilk technology provides Menicon PremiO lenses with an advanced hydrophilic molecule which provides wettability levels never seen before with any other SiH contact lens (Figures 5 and 6).

Figure 5
Wettability of different silicone hydrogel contact lenses measured using the captive bubble method.

Figure 6
Wettability of different silicone hydrogel contact lenses measured with an advanced interferometric technique.


With the introduction of SiH lenses, the rigidity modulus of the material has received increasing attention in the contact lens field. It describes how well a material resists deformation and is defined as the force per unit required to compress the material by a given amount.32 First generation silicone hydrogel contact lenses are associated with higher incidences rates of mechanically-related adverse events and this might be partly related to their high modulus of rigidity. 6,7 Although contact lenses with low modulus of rigidity are associated to a lower incidence of mechanically-related adverse events, the challenge for the contact lens manufacturer consists of the development of contact lenses with intermediate modulus of rigidity which not only prevent mechanically-related adverse events, but also provide adequate lens handling and fitting characteristics. Menicon PremiO with MeniSilk and Nanogloss has a well balanced modulus of rigidity which minimizes mechanically-related adverse events, while maintaining excellent handling and fitting characteristics.


Clinical studies have shown remarkable clinical performance and comfort levels with the Menicon PremiO lens. 28,29 Additionally, the availability of this lens in two different base curves (8.3 and 8.6 mm) allows a better lens fitting than those SiH contact lenses available in one single base curve. The latter is of special relevance taking into account the intimate lens-to-cornea curvature relationship observed with SiH lenses manufactured with relatively high modulus of rigidity. A previous study found that when two lens base curves are available in a silicone hydrogel lens, around 74% of subjects perform better with the flatter base curve, whereas 24% perform better with the steeper base curve. 27

The Menicon PremiO lens, available in two different base curves, allows contact lens practitioners a wider choice in order to find a better lens fit in a broader range of patients. Additionally, the two week replacement of the lens allows a safer modality of lens wear than those lenses with longer replacement cycles.


Contact lens multipurpose solutions should provide a broad spectrum of disinfection against pathogenic microorganisms without inducing toxic effects in the ocular structures. Several toxic reactions on the ocular structures have been identified when certain SiH contact lenses are used with specific contact lens solutions. 35 These toxic reactions might occur when antimicrobial agents come in contact with the ocular structures.36 Typically, toxic effects induced by contact lens care regimens include signs of corneal staining, limbal and conjunctival hyperaemia as well as a variety of other symptoms. Additionally, it has been found that the higher the toxicity of the SiH lens/multipurpose solutions combination, the higher the incidence of corneal infiltrative events. 37

A compromised corneal epithelium is more prone to pathogenic microorganism adherence38 and thus, to the incidence of severe ocular adverse events such as microbial keratitis, which in severe cases could induce permanent reduction of visual acuity. 39 Based on all the above, the use of a SiH lens compatible with the different multipurpose solutions currently available on the market is of key importance. The Menicon PremiO lens has shown excellent levels of compatibility with multipurpose solutions formulated with both polyhexamethylene biguanide (PHMB) and polyquad as disinfecting agents. 40

Figure 7.
Overall corneal staining observed in two silicone hydrogel lenses used in combination with three multipurpose solutions. For each pair of bars of the same colour, the first bar represent the results found with the Menicon PremiO lens, whereas the second bar represent the results found with the Acuvue Oasys lens.


The Menicon PremiO with MeniSilk and Nanogloss technologies is the latest and most advanced SiH contact lens on the market. This lens has been developed taking into account the problems found in early generations of SiH contact lenses. It’s well balanced combination in material and surface properties, as well as its remarkable compatibility with different contact lens care regimens warrant an excellent clinical performance and extraordinary levels of comfort.


  1. Tanaka K, Takahashi K, Kanada M, Shinji K, Tatsutoshi N. Copolymer for soft contact lens, its preparation and soft contact lens made thereof. US Patent 4139513.
  2. Holden BA, Sweeney DF, Vannas A, Nilsson KT, Efron N. Effects of long-term extended contact lens wear on the human cornea. Invest Ophthalmol Vis Sci 1985;26:1489-501.
  3. Keay L, Sweeney DF, Jalbert I, Skotnitsky C, Holden BA. Microcyst response to high Dk/t silicone hydrogel contact lenses. Optom Vis Sci 2000;77:582-5.
  4. Covey M, Sweeney DF, Terry R, Sankaridurg PR, Holden BA. Hypoxic effects of high Dk soft contact lens wearers are negligible. Opt Vis Sci 2001;78:95-9.
  5. Santodomingo-Rubido J, Wolffsohn JS, Gilmartin B. Long-term changes in ocular physiology, tear film characteristics and symptomatology with silicone hydrogel contact lens wear. Optom Vis Sci 2006;83:73-81.
  6. Santodomingo-Rubido J, Wolffsohn JS, Gilmartin B. Adverse events and discontinuations over 18 months of silicone hydrogel contact lens wear. Eye Contact Lens 2007;33:288–292.
  7. Santodomingo-Rubido J, Wolffsohn JS, Gilmartin B. Conjunctival epithelial flaps with 18 months silicone hydrogel contact lens wear. 2008;34:35-8.
  8. Holden BA, Mertz GW. Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses. Invest Ophthalmol Vis Sci. 1984 Oct;25(10):1161-7
  9. Harvitt DM, Bonanno JA. Re-evaluation of the oxygen diffusion model for predicting minimum contact lens Dk/t values needed to avoid corneal anoxia. Optom Vis Sci 1999;76:712-9.
  10. French K. Contact lens material properties. Part 1 – Wettability. Optician 2005;230:6022 20-7.
  11. French K. Contact lens material properties. Part 2 – Mechanical behaviour and modulus. Optician 2005;230:6026 29-34.
  12. Tighe BJ. Contact lens materials. En: A.J. Phillips and L. Speedwell ed. Contact Lenses. 4th edition. Oxford: Butterworth-Heinemann; 1997: 67-8.
  13. Morgan PB, Woods CA, Jones DJ, Efron N, Tan K-O, Pesinova A, Grein H-J, Santodomingo J, Runberg S-E, Tranoudis IG, Candirnos A, Itoi M, van der Worp E, Helland M, Phillips G, Gonzalez-Meijome JM, Belousov V. Internacional contact lens prescribing in 2007. Contact Lens Spectrum 2008;23:36-41.
  14. Schlanger JL, Schwartz CA, Leser E. Happy patients: connecting comfort and compliance. Spectrum 1993;8:45-7.
  15. Riley C, Young G, Chalmers R. Prevalence of ocular surface symptoms, signs, and uncomfortable hours of wear in contact lens wearers: the effect of refitting with daily-wear silicone hydrogel lenses (senofilcon). Eye Contact Lens 2006;32:281-6.
  16. Begley CG, Caffery B, Nichols KK, et al. Responses of contact lens wearers to a dry eye survey. Optom Vis Sci 2000;77:40-6.
  17. Vajdic C, Holden BA, Sweeney DF, et al. The frequency of ocular symptoms during spectacle and daily soft and rigid contact lens wear. Optom Vis Sci 1999;76:705-11.
  18. Maldonado-Codina C, Efron N. Impact of manufacturing technology and material composition on the clinical performance of hydrogel lenses. Optom Vis Sci 2004;81:442-54.
  19. Morgan PB, Efron N. In vivo dehydration of silicone hydrogel contact lenses. Eye Contact Lens 2003;29:173-6.
  20. Jones L, Senchyna M, Glasier MA, Schickler J, Forbes I, Louie D, May C. Lysozyme and lipid deposition on silicone hydrogel contact lens materials. Eye Contact Lens 2003;29:S75-9.
  21. Tighe B. Silicone hygrogel materials: how do they work? In: Sweeney DF, ed. Silicone Hydrogels: the rebirth of Continuous Wear Contact Lenses. Oxford: Butterworth-Heinemann, 2000:1-21.
  22. Steffen R, Schnider C. A next-generation silicone hydrogel lens for daily wear. Optician 2004;227:10-13.
  23. Santodomingo-Rubido J, Mori O, Kawaminami S. Cytotoxicity and antimicrobial activity of six multipurpose soft contact lens disinfecting solutions. Ophthal Physiol Opt 2006;26:476-482.
  24. Santodomingo-Rubido J. The comparative clinical performance of a new polyhexamethylene biguanide- vs a polyquad-based contact lens regime with two silicone hydrogel contact lenses. Ophthal Physiol Opt 2007;27:168-73.
  25. Efron N, Brennan NA, Currie JM et al. Determinants of the initial comfort of hydrogel contact lenses. Am J Optom Physiol Opt 1986;63:819-23.
  26. Mc Monnies CW. The critical comfort of soft conact lenses. Clin Exp Optom 1997;80:53-8.
  27. Dumbleton KA, Chalmers R, McNally J, et al. Effect of lens base curve on subjective comfort and assessment of fit with silicone hydrogel continuous wear contact lenses. Optom Vis Sci 2002;79:633-7.
  28. Santodomingo-Rubido J, Rubido-Crespo M-J. The clinical investigation of the base curve and comfort rate of a new prototype silicone hydrogel contact lens. Eye Contact Lens 2008 (in press).
  29. Clinical evaluation of PremiO versus Oasys over six months of extended wear. Datos de archivo Menicon
  30. French K. Contact lens material properties. Part 1 – Wettability. Optician 2005;230:6022 20-7.
  31. Maruyama K, Yokoi N, Kinoshita S. A new interference-based in vitro technique for the wettability assessment of soft contact lenses. Poster presented at the 2007 BCLA Conference. Manchester, UK.
  32. French K. Contact lens material properties. Part 2 – Mechanical behaviour and modulus. Optician 2005;230:6026 29-34.
  33. Holden BA, Mertz GW. Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses. Invest Ophthalmol Vis Sci. 1984;25:1161-7.
  34. Harvitt DM, Bonanno JA. Re-evaluation of the oxygen diffusion model for predicting minimum contact lens Dk/t values needed to avoid corneal anoxia. Optom Vis Sci 1999;76:712-9.
  35. Carnt NA, Willcox MDP, Evans VE, Naduvilath TJ, Tilia D, Papas EB, Sweeney DF, Holden BA. Corneal Staining with Various Contact Lens Solution - Silicone Hydrogel Lens Combinations and its Significance: The IER Matrix Study. Contact Lens Spectrum 2007;22:38-43.
  36. Gilbert P, Moore LE. Cationic antiseptics: diversity of action under a common epithet. J Appl Microbiol 2005;99:703-15.
  37. Carnt N, Jalbert I, Stretton S, Naduvilath T, Papas E. Solution toxicity in soft contact lens daily wear is associated with corneal inflammation. Optom Vis Sci 2007;84:309-15.
  38. Ren DH, Yamamoto K, Ladage PM, et al. Adaptive effects of 30-night wear of hyper-O2 trasmissible contact lenses on bacterial binding and corneal epithelium. Ophthalmology 2002;109:27-40.
  39. Morgan PB, Efron N, Hill EA, Raynor MK, Whiting MA, Tullo AB. Incidence of keratitis of varying severity among contact lens wearers. Br J Ophthamol 2005;89:430-36.
  40. Compatibility of two new silicone hydrogel contact lenses with three soft contact lens multipurpose solutions. Menicon data on file.



Diameter 14.0 mm
Base curves 8.6 and 8.3 mm
Center thickness 0.08 mm (-3.00D)
Dk/t 161
Power range +6.00D to -6.50D (0.25D steps)
+6.50D to -13.00D (0.50D steps)

* Products and availability may vary by country.

Menicon© Menicon Co., Ltd. All rights reserved.