More comfort for RGP contact lens wearers 2
- Vitamin C glucoside
- Hyaluronic acid
- Disinfecting efficacy
- Cleaning efficacy
- Low toxicity
ε-PL is a natural homopolymer of the essential
amino acid L-lysine.
It is naturally secreted by various Streptomycetaceae bacteria and some filamentous fungi. Industrial production of ε-PL is carried out by aerobic fermentation of Streptomyces albulus strain.
Since ε-Polylysine is natural homopolymer of the essential amino acid L-lysine, the toxicity is lower than other cationic disinfectants used in commercial available multi-purpose solutions.
Because of the cationic nature of ε-PL, it shows high and wide antimicrobial activity. The predominant mechanism for ε-PL’s antimicrobial activity is its electrostatic adsorption onto the cell surface of microorganisms leading to stripping of the outer membrane and abnormal distribution of cytoplasm.
No degradation/denaturation was observed after boiling at 100°C for 30 min or autoclaving at 120°C for 20 min or storing at room temperature for 3 years.
is a high molecular cellulose derivative, that is made
from the naturally existing Cellulose fiber.
HPMC adjusts viscosity of the solution to keep good balance that provide good feeling for rubbing and comfortable cushioning effect for insertion.
Hyaluronic Acid (HA)
Hyaluronic acid possesses an excellent ability to retain moisture and has a high affinity to the mucin layer on the corneal epithelium therefore it can support corneal epithelial repair.
HCO-60 (Macrogolglycerol Hydroxystearate 60).
HCO-60 is a non-ionic surfactant which is made from vegetable seed oil.
HCO-60 has a good balance between less cytotoxicity (less irritation) and higher cleaning efficacy for lipids. Also HCO-60 has the ability to prevent lysozyme from denaturing.
Vitamin C Glucoside (VCG)
VCG is a stabilized vitamin C for aqueous products and once introduced to the eye, VCG decomposes into vitamin C and glucose by enzymatic (glucosidase) reaction. The functions of vitamin C are well known for an antioxidant, antiinflammatory and collagen production.
Efficacy of MPS against biofilm
Lens case vial
Put staphylococcus epidermidis (isolated from contact-lens users) together with medium (as source of nutrition), subsequently incubate the mixture enough time for forming biofilm inside the lens case.
Replace the medium to MPS and leave them for 4 hours, then stain the remaining biofilm by crystal violet.
Image of biofilm treated by MENICARE PURE [ TEST LIVE (Green) / DEAD (Red) ]
Almost all bacteria in the biofilm were destroyed by MENICARE PURE solution.
S.epidermidis biofilms were observed by crystal-violet staining and LIVE/DEAD vital dye assay with laser confocal microscopy after 4 hour-treatment with each MPS(3).
[ Lipid solubilization ]
Artificial lipid (Triglyceride) plates with 1% orange dye.
*Triglyceride is one of the main lipids in tears
Measure the absorbance of test solution after 1, 2, 4 and 8 hours to assay the amount of lipid solubilized by surfactant.
[ Lysozyme ]
Denatured protein can cause:
- Deposits on RGP surface
- Discomfort & allergy
Natural-origin surfactant prevents protein from denaturating.
Lysozyme was dissolved in each solution tube (final concentration 0.15 %) then heated at 70°-90° for 5 minutes. Denatured lysozyme becomes visible as whitish deposits.
[ Cytotoxicity test according to ISO 10993-5 (Colony forming assay) ]
IC50 : half maximal (50%) inhibitory concentration
Higher IC50 values mean lower cytotoxicity.
[ Manufacturing Process ]
This method eliminates the microorganisms and insoluble particles of all sizes.
- Disinfecting : effective after 30 minutes
Throw away 3 months after opening Expiry date : 3 years
Menicon Z were soaked in MENICARE PURE or saline for 6 hours, after which the coloured (blue) saline was dropped on to the lens surface.
The dropper tip is sealed.
To open, screw the cap clockwise.
The spike inside the cap will pierce the seal.
Wash your hands thoroughly before handling your contact lenses:
- Rub the lens carefully with several drops of MENICARE PURE for 20 seconds.
- Place the lenses in the right and left lens holder and rinse them with MENICARE PURE.
- Fill the lens case with MENICARE PURE and soak the lenses for at least 30 minutes or overnight.
- Before insertion, rinse the lenses with MENICARE PURE.
- Keep the lens case clean and dry after use.
Lenses may be stored in the unopened case until ready to wear, up to a maximum of 30 days. If you store your lenses for longer periods of time, they must be cleaned and disinfected with MENICARE PURE solution every 30 days.
Menicon recommends to use PROGENT intensive cleaner once a week.
Safe and convenient packaging
- For better sterility and integrity
- Easy handling bottle
One touch cap.
Health and safety enhanced.
The integrity of the container is preserved, the opening and closing are automatic in one step.
The cap remains attached to the bottle thus limiting the risk of contamination.
- Antimicrobial properties of a new rigid gas-permeable contact lens multipurpose solution formulated with Polylysine as disinfecting agent. Osamu Mori, MS and Megumi Toyohara, MS. R&D center, Menicon Co. Ltd., Kasugai, JAPAN. Poster BCLA 2014.
- Efficacy of rigid gas permeable contact lens multi-purpose care solutions against Acanthamoeba Simon Kilvington. University of Leicester, Leicester, UK .Poster BCLA 2014.ester, Leicester, UK 2
- Efficacy of multipurpose RGP contact lens solutions against bacteria under planktonic and biofilm conditions. Miya Nomachi, Osamu Mori, R&D center, Menicon Co. Ltd., Kasugai, JAPAN Simon Kilvington University of Leicester, Leicester, United Kingdom